Furthermore, evidence has emerged that small, non-fibrillar protein aggregates known as oligomers are toxic to the cells of an affected organ, and that amyloidogenic proteins in their fibrillar form may be relatively benign.
32.
Furthermore, evidence has emerged that small, non-fibrillar protein aggregates known as oligomers are toxic to the cells of an affected organ, and that amyloidogenic proteins in their fibrillar form may be relatively benign.
33.
When microglia interact with the deposited fibrillar forms of ?-amyloid it leads to the conversion of the microglia into an activated cell and results in the synthesis and secretion of cytokines and other proteins that are neurotoxic.
34.
Despite these differences in structural and self-assembly mechanisms, both EAS and DewA form robust fibrillar monolayers, meaning that there must exist several pathways, protein sequences and tertiary conformations able to self-assemble into amphipathic monolayers.
35.
Sabot-shaped teeth & mdash; rods with a groove along one side & mdash; are associated with diets of crossed-fibrillar cellulose-walled algae, such as the Siphonocladaceae and Cladophorales, whereas blade-shaped teeth are more generalist.
36.
It is evident from the known collagen assembly that the tensile strength is basically due to fibrillar arrangement of collagen molecules, which self-assemble into microfibrils in a longitudinal as well as lateral manner producing extra strength and stability to the collagen assembly.
37.
However, if the conventional reaction is seeded by 1-4 mg ( seed quantities ) of added pre-synthesized polyaniline nanofibers, ( nanofiber seeds could be prepared from interfacial polymerization ) the bulk morphology changes dramatically from granular to nano-fibrillar.
38.
Oxidative polymerization can be also seeded by other nanostructure materials such as vanadium pentoxide nanofibers, where V2O5 nanofibers ( i ) Rapidly initiate fibrillar polymer growth ( ii ) Slowly dissolve in aq . 1.0 M HCl, which eliminates template removal steps.
39.
APP is best known as the precursor molecule whose proteolysis generates beta amyloid ( A? ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.
40.
Repetitive mild traumatic brain injury ( TBI ), now recognized as a central component of brain injury in contact sports, especially American football, and the concussive force of military blasts . can lead to chronic traumatic encephalopathy ( CTE ) that is characterized by fibrillar tangles of hyperphosphorylated tau.
