Within the talk section there is some discussion about how impactful frameshift mutations are concerning the structure of proteins resulting from gene expression.
32.
An experiment to determine the accuracy of this newer sequencing method tested for 21 genes and had no false positive calls for frameshift mutations.
33.
The methods include providing a tissue or fluid sample and conducting gene analysis for frameshift mutation or a protein from this type of mutation.
34.
A frameshift mutation is not the same as a single-nucleotide polymorphism in which a nucleotide is replaced, rather than inserted or deleted.
35.
Such frameshift mutations can lead to deleterious effects on the peptide chain, including insertion of different amino acids or premature truncation of the protein.
36.
Mutations that disrupt the reading frame sequence by indels ( deletions ) of a non-multiple of 3 nucleotide bases are known as frameshift mutations.
37.
Frameshift mutations have been proposed as a source of biological novelty, as with the alleged creation of nylonase, however, this interpretation is controversial.
38.
An environmental study, specifically the production of UV-induced frameshift mutations by DNA polymerases deficient in 32 ?! 52 exonuclease activity was done.
39.
The mutants produced by Crick and Brenner could not produce functional rIIB protein because the insertion or deletion of a single nucleotide caused a frameshift mutation.
40.
However, many other genes have been discovered which did evolve by gene duplication followed by a frameshift mutation affecting at least part of the gene.
