In clinical trials, velusetrag was efficacious and well tolerated in patients with chronic constipation, and showed accelerated intestinal and colonic transit after single dosing and accelerated gastric emptying after multiple dosing.
32.
|Amylin ( or Islet Amyloid Polypeptide ) | | IAPP | | pancreas | | amylin receptor | | | | slowing down gastric emptying, inhibition of digestive secretion, and reducing food intake
33.
The anorectic properties of GLP-1 and its peptide analogs are thought to be due in part to both inhibition of gastric emptying and deactivation of central satiety centers coupled with reduction of energy intake.
34.
Administering activated charcoal later than 2 hours can be considered in patients that may have delayed gastric emptying due to co-ingested drugs or following ingestion of sustained-or delayed-release paracetamol preparations.
35.
Two of these have been identified, one called calabarine with atropine-like effects, and the other, the drug physostigmine, used in the treatment of anticholinergic syndrome, myasthenia gravis, glaucoma and delayed gastric emptying.
36.
The mechanism of DPP-4 inhibitors is to increase incretin levels ( GLP-1 and GIP ), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.
37.
However, GSK716155 rapidly reduces food intake and inhibits gastric emptying in preclinical studies within minutes of administration, suggesting that direct central nervous system penetration of GLP-1R agonists may not be required for GLP-1R dependent actions in the brain.
38.
Gastroparesis ( delayed gastric emptying ) may occur and is due to metabolic causes ( e . g . poorly controlled diabetes mellitus ), decreased gastric motility ( e . g . due to head injury ) or pyloric obstruction ( e . g . pyloric stenosis ).
39.
"' Mosapride "'is a gastroprokinetic agent that acts as a selective 5HT 3 antagonist . which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans, and is used for the treatment of gastritis, gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome.
40.
Cetin K, Gungor B, Isik A, Ahmet D, Filiz A, Nevzat A, Sadakat O, Cengiz D, Zeynel M . The effect of pneumatic balloon dilatation on gastric emptying in patients with achalasia . Hepatogastroenterology . 2003 Dec; 50 Suppl 2 : ccci-cccii.
