These genes play a role in germ line development to localize nanos mRNA to the posterior and localize germ cell determinants.
32.
After the 10th division, the pole cells form at the posterior end of the embryo, segregating the germ line from the syncytium.
33.
Clonal analysis of X-chromosome inactivation and the origin of the germ line in the mouse embryo . " J . Embryol . exp.
34.
Moreover, in 2007, Yamanaka and his colleagues found iPS cells with germ line transmission ( via selecting for Oct4 or Nanog gene ).
35.
The most obvious explanation lies in the much greater number of cell divisions in the male germ line than in the female germ line.
36.
Probably for another 100 years, it will be viewed as unethical and not patentable to make changes in the germ line of human beings.
37.
There are also concerns about genetically engineering human egg cells-- so called " germ line engineering "-- because it involves modifying the human genome.
38.
For instance two dominant-negative germ line mutations were identified in the Ataxia telangiectasia mutated ( ATM ) gene which increases susceptibility to breast cancer.
39.
The most obvious explanation lies in the much greater number of cell divisions in the male germ line than in the female germ line.
40.
In the mammalian germ line DNA, demethylation occurs immediately following fertilization in the zygote, so that relatively few genes are silenced at that time.
