A diagnosis can also be implied by biochemical abnormalities such as high alkaline phosphatase, angiotensin-converting enzyme, and immunoglobulin levels, or by cell analysis showing " crinkled paper " cytoplasm and glycolipid-laden macrophages.
32.
However, in practice the term glycan may also be used to refer to the carbohydrate portion of a glycoconjugate, such as a glycoprotein, glycolipid, or a proteoglycan, even if the carbohydrate is only an oligosaccharide.
33.
According to ( a site about an interesting drug to stop the damage ) the kidneys and intestine both have the same Gb3 glycolipid receptor for the toxin; the kidneys thus are affected if it gets to the bloodstream.
34.
"' Dinutuximab "'( tradename Unituxin ) is a monoclonal antibody that targets glycolipid GD2, expressed on neuroblastoma cells and on normal cells of neuroectodermal origin, including the central nervous system and peripheral nerves.
35.
Two of them are subunits of hexosaminidase A; the third is a small glycolipid transport protein, the GM2 activator protein ( GM2A ), which acts as a substrate-specific folding ( disrupting function ) or disable intracellular transport.
36.
L2, 3, 5, 7, 9, the terminal tetrasaccharide portion of the oligosaccharide ( lacto-N-neotetraose ) is the same tetrasaccharide as that found in paragloboside, a precursor for ABH glycolipid antigens found on human erythrocytes.
37.
This discovery assisted other scientists in the elucidation of similar glycolipid storage diseases such as Gaucher's disease and cerebroside-3-sulfate, a lipid found in high concentrations in patients afflicted with Metachromatic leukodystrophy were known to have helped in the later-day therapeutic protocols.
38.
A glycolipid is a lipid with a sugar attached : ) But this is an encyclopedia, you can search for answers yourself on it, and in my experience very few people are likely to tell you any more than that : ( HS7 18 : 55, 29 March 2007 ( UTC)
39.
The disease causing catabolic enzyme deficiency of hexosaminidases was demonstrated with four different substrates ( p nitrophenyl-?-D-N-acetylglucosaminide, p-nitrophenyl-?-D-N-acetylgalactosaminide, glycolipid [ 3H ] GA2 and [ 3H ] globoside ) in four different organs and published in 1968.
40.
Additionally, human and some bacterial GALE isoforms reversibly catalyze the formation of UDP-" N "-acetylgalactosamine ( UDP-GalNAc ) from UDP-" N "-acetylglucosamine ( UDP-GlcNAc ) in the presence of NAD +, an initial step in glycoprotein or glycolipid synthesis.
