In blood plasma, haptoglobin binds free hemoglobin ( Hb ) released from erythrocytes with high complex will then be removed by the reticuloendothelial system ( mostly the spleen ).
32.
She traced this 16q fragile site through a multigenerational family and, together with Hecht and Everett Lovrien, she linked the 16q fragile site to the gene for haptoglobin.
33.
In severe extra-vascular hemolysis, haptoglobin levels can also be low, when large amount of hemoglobin in the reticuloendothelial system leads to transfer of free hemoglobin into plasma.
34.
The first step in the killing mechanism is the binding of TLF to high affinity receptors the haptoglobin-hemoglobin receptors that are located in the flagellar pocket of the parasite.
35.
The second research focus was on gene product analysis, where he used starch gel electrophoresis to explore the genetic diversity of plasma proteins ( such as haptoglobins and transferrins ).
36.
Under normal conditions the formation of haptoglobin-hemoglobin complexes prevents glomerular filtration, but if the hemolysis is extensive haptoglobin s uptake capacity is exceeded and hemoglobin can appear in urine.
37.
However, if you have the misfortune to possess the genotype haptoglobin 2-1, the study shows that this same treatment can drastically decrease your HDL function and cause cardiovascular disease.
38.
The mapping of haptoglobin to 16q was the second instance in which a human gene was mapped to a specific autosome ( non-sex chromosome ), presaging the Human Genome Project.
39.
A decrease in haptoglobin can support a diagnosis of hemolytic anemia, especially when correlated with a decreased red blood cell count, hemoglobin, and hematocrit, and also an increased reticulocyte count.
40.
The protein components of TLF-1 are haptoglobin related protein ( HPR ), apolipoprotein L-1 ( apoL-1 ) and apolipoprotein A-1 ( apoA-1 ).
