It can also be hepatotoxic in patients with severe liver impairment, and patients with extensive liver tumors due to metastatic disease have developed progressive hepatic coma and death during azacitidine treatment, especially when their albumin levels are less than 30 g / L . It is contraindicated in patients with advanced malignant hepatic tumors.
32.
Both DMAU and trestolone ( 7?-methyl-19-nortestosterone; MENT ) showed potential signs of hepatotoxicity whereas 11?-methyl-19-nortestosterone 17?-dodecylcarbonate ( 11?-MNTDC ) showed few to no such effects, suggesting that the C7? methyl group of DMAU and trestolone could be an important contributing factor to their hepatotoxic potential.
33.
However, niacin products sold as " no-flush ", " i . e . " not having side-effects such as " niacin flush ", do not contain free nicotinic acid and are therefore ineffective at raising HDL, while products sold as " sustained-release " may contain free nicotinic acid, but " some brands are hepatotoxic "; therefore the recommended form of niacin for raising HDL is the cheapest, immediate-release preparation.
