| 31. | Some cancers are associated with anomalies in constitutive heterochromatin and the proteins involved in its formation and maintenance.
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| 32. | H4K20me3 is observed to be concentrated in heterochromatin and reductions in this trimethylation are observed in cancer progression.
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| 33. | This is in agreement with findings that show that there is an increase in inactive heterochromatin during differentiation.
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| 34. | PRC2 acts to create heterochromatin in these regions through similar mechanisms to the mechanism used to repress genes.
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| 35. | However, on a larger scale, chromosomes are heterogeneous in the context of euchromatin and heterochromatin composition.
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| 36. | These two complexes localize in a siRNA-dependent manner on chromosomes, at the site of heterochromatin assembly.
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| 37. | CAF-1 is required for the spatial organization and epigenetic marking of heterochromatin domains in pluripotent embryonic cells.
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| 38. | There are also three additional euchromatin / heterochromatin transition regions for a total of four on the Y chromosome.
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| 39. | The rest of the genes lay on the periphery of the sub-nuclear organelle in silenced heterochromatin state.
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| 40. | This level of chromatin structure is thought to be the form of heterochromatin, which contains mostly transcriptionally silent genes.
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