This change in bone turnover is likely to be the reason for numerous effects seen in hypervitaminosis A, such as hypercalcemia and numerous bone changes such as bone loss that potentially leads to osteoporosis, spontaneous bone fractures, altered skeletal development in children, skeletal pain, radiographic changes, and bone lesions.
32.
The causes of Mertz's death and Mawson's related illness remain uncertain; a 1969 study suggested hypervitaminosis A, presumably caused by the men eating the livers of their Sir Edmund Hillary described Mawson's month-long journey as " probably the greatest story of lone survival in Polar exploration ".
33.
With six dogs between them ( with a liver on average weighing 1 kg ), it is thought that the pair ingested enough liver to bring on a condition known as Hypervitaminosis A . However, Mertz may have suffered more because he found the tough muscle tissue difficult to eat and therefore ate more of the liver than Mawson . While both men suffered, Mertz suffered more severely.
34.
You don't have to predicate a theory of this sort to explain the soles coming off your feet . " A 2005 article in " The Medical Journal of Australia " by Denise Carrington-Smith suggested it may have been " the psychological stresses related to the death of a close friend and the deaths of the dogs he had cared for ", and a switch from a predominately vegetarian diet that killed Mertz, not hypervitaminosis A.
35.
Apart from this paper, in this period, Hugh had published on a variety of topics, including nutritional deficiency in general and in more specific aspects, such as the relation of deficiencies of vitamin A and essential fatty acids to follicular hyperkeratosis in rats, lesions of mucocutaneous zones in the rat in pyridoxine deficiency, ascorbic acid in hypervitaminosis A in guinea pigs, polycythemia in the rat in pyridoxine deficiency, skin permeability in deficiency of essential fatty acids, vitamin deficiencies in alcoholism, vitamins and the nervous system, and nutritional neuropathy in chronic thiamine deficiency in the rat.
