A Cochrane review found that both types of vaccines offer significant protection, for at least two years with the inactivated vaccine and at least five years with the attenuated vaccine.
32.
But since 2-month-old children now receive immunizations against several other diseases at the same time, replacing oral polio vaccine with inactivated vaccine will add one more shot to the existing schedule.
33.
Although inactivated vaccine provides maximum safety, there is experimental evidence that PPV can be sufficiently attenuated so that it is unlikely to cause reproductive failure even if inadvertently administered during gestation.
34.
Since the virus in an inactivated vaccine has been killed, there should generally ( so long as the virus has been correctly inactivated ) be no risk of infection or transmission.
35.
It was later discovered that it was not the HTMV, but rather a subsequent inactivated vaccine ( DTP or IPV for different children ), that caused the increase in female mortality.
36.
Testing the vaccines on 18 monkeys, she and her team discovered that the inactivated vaccine manufactured by Cutter Laboratories contained residual live poliovirus, resulting in the monkeys showing polio-like symptoms and paralysis.
37.
And in September, Sanofi Pasteur reported in a press release that an inactivated vaccine adjuvanted with the company's own proprietary formula induced EU-accepted levels of protection after two doses of 1.9 mcg ."
38.
In fact, a policy statement adopted by the advisory committee Wednesday made clear that the " sequential schedule " was only an intermediate step to replacing oral vaccine entirely with the inactivated vaccine.
39.
World Health Organization ( WHO ) experts have suggested that the priority should be to develop inactivated vaccines and other non-live vaccines, which are safe to use in pregnant women and those of childbearing age.
40.
Advisers to the committee said it was probable that the new, " sequential " schedule _ use of the inactivated vaccine, followed by use of the oral vaccine _ would sharply reduce the cases of vaccine-associated polio.
