Accumulation of iron in a single organ does not provide proper representation of the total body iron overload.
32.
Repeated blood transfusions can lead to build-up of iron overload, ultimately resulting in iron toxicity.
33.
Medical studies indicate that one in every 200 people have the double gene and the potential for iron overload.
34.
There are also juvenile forms of hereditary haemochromatosis that present in childhood with the same consequences of iron overload.
35.
Ferroportin Q248H mutation in African families with dietary iron overload showed lower mean cell volume and higher ferritin concentration.
36.
The probable cause of African iron overload is the combination of excess iron intake and functional changes in ferroportin.
37.
These individuals are likely to have liver and spleen iron overload, primarily in Kupffer cells and other macrophages.
38.
People with two copies of a defective gene on chromosome 6 are the most likely to develop iron overload disease.
39.
Spherocytosis patients who are heterozygous for a hemochromatosis gene may suffer from iron overload despite the hemochromatosis genes being recessive.
40.
For instance, a severe form of iron overload, juvenile hemochromatosis, is a result of severe hepcidin deficiency.
