They can be found in other tissues, such as lymph nodes, particularly in association with the condition Langerhans cell histiocytosis ( LCH ).
32.
It used, often in combination with other cytotoxic agents, to treat various kinds of histiocytosis, including Erdheim Chester disease and Langerhans cell histiocytosis,
33.
It was demonstrated that Langerhans cells in HPV-induced cervical lesions were spherical, lacked dendrites, and secreted the suppressive cytokine IL-10 " in vivo ".
34.
Transfected Langerhans cells migrate out of the skin ( within 12 hours ) to the draining lymph node where they prime secondary B-and T-cell responses.
35.
"Twenty-four hours after UVA exposure, there is a decrease in Langerhans cells, which are the home base for T-cells in the skin, " she says.
36.
This led to a new understanding of the construction of the epidermis, and also the discovery of a novel function of the epidermal Langerhans cells.
37.
The immune system and blood cells, called Langerhans cells, macrophages and lymphocytes, are found along with epithelial cells, which form the tunnels of the blood vessels.
38.
These receptors belong to the seven transmembrane G-protein-coupled receptor ( GPCR ) family and are predominantly expressed on human T-cells, dendritic cells and macrophages, Langerhans cells.
39.
Abigail is eventually found to have a granuloma pressing against her pituitary gland, evidently causing her apparent " dwarfism ", which points to Langerhans cell histiocytosis.
40.
She pushed forward the study of dendritic cells, realising that they were derived from Langerhans cells and played an important role in initiating and promoting immune reactions.
