Some people have raised concerns about the use of this material, particularly in munitions, because of its mutagenicity, teratogenicity in mice, and neurotoxicity, and its suspected carcinogenic potential.
32.
However authors still cautioned against using high doses ( > 3g-5g ) in those with impaired kidney functioning, and suggested further studies are needed relating to claims of mutagenicity and carcinogenicity.
33.
The fact that expression of this gene is an indicator of DNA damage has been exploited to construct an " in vitro " test for mutagenicity, the GADD45a-GFP GreenScreen HC assay.
34.
During the early 1970s, the society played a significant part in the development of the US Toxic Substances Control Act of 1976, enabling the United States Environmental Protection Agency to include mutagenicity data in regulatory decisions.
35.
The carcinogenicity of ptaquiloside was proven in 1984, and ptaquiloside was shown to be responsible for the characteristic biological effects of bracken, such as acute bracken poisoning, bright blindness in sheep, mutagenicity, clastogenic effects and genotoxicity.
36.
Lamivudine treatment has been shown to restore zidovudine sensitivity of previously resistant HIV . Lamivudine showed no evidence of carcinogenicity or mutagenicity in " in vivo " studies in mice and rats at doses from 10 to 58 times those used in humans.
37.
Although the concentrations measured of benzo [ " c " ] fluorene are quite low, when corrected for mutagenicity, benzo [ " c " ] fluorene is the most important PAH of those that were measured in terms of possible health risks.
38.
This was the exciting era of environmental toxicology with predictive mutagenicity and carcinogenicity testing of thousands of chemicals in widespread use in pharmaceutical, cosmetic, chemical and food industries and a lot of time was spent visiting and advising companies on the impact of results on their businesses.
39.
Positive results from mutagenicity analysis via the Ames test of compounds commonly found in preparations labelled " pangamic acid " including diisopropylamine dichloroacetate, diisopropylamine, dichloroacetate, as well as dimethylglycine mixed with sodium nitrite suggests there may be concern for the development of cancer with the use of these substances.
40.
For these, a number of tests are performed, lasting less than a month ( acute ), one to three months ( subchronic ), and more than three months ( chronic ) to test general toxicity ( damage to organs ), eye and skin irritancy, mutagenicity, carcinogenicity, teratogenicity, and reproductive problems.
