Although miR-133 is known to promote MEF-2-dependent myogenesis, it also inhibits Runx2-mediated osteogenesis.
32.
Moreover, signaling pathways related to neurogenesis and myogenesis were also investigated by studying gene expression or generating mutants of P19 cells.
33.
EZH2 also has critical roles in stem cell maintenance and cell lineage determination, such as osteogenesis, myogenesis, lymphopoiesis and hematopoiesis.
34.
The embryological origin of smooth muscle is usually of mesodermal origin, after the creation of muscle fibers in a process known as myogenesis.
35.
Myogenin is required for the fusion of myogenic precursor cells to either new or previously existing fibers during the process of differentiation in myogenesis.
36.
The significance of alternative splicing was elucidated using microarrary analysis of differentiating C2C12 myoblasts . 95 alternative splicing events occur during C2C12 differentiation in myogenesis.
37.
Although most events throughout myogenesis that involve Myf5 are controlled through the interaction of multiple enhancers, there is one important early enhancer that initiates expression.
38.
Studies support this finding as in the absence of PAX3, there is Pitx2 expression deficit and thus, MyoD does not express itself in limb myogenesis.
39.
The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.
40.
Although the specific roles and dependency of Myf5 in adipogenesis and neurogenesis have remained to be explored, these findings show that Myf5 plays roles outside of myogenesis.
