Nuclear pores, which provide aqueous channels through the envelope, are composed of multiple proteins, collectively referred to as nucleoporins.
32.
Nuclear import depends on the importin binding its cargo in the cytoplasm and carrying it through the nuclear pore into the nucleus.
33.
The importin? & mdash; importin? & mdash; cargo complex is then directed towards the nuclear pore and diffuses through it.
34.
With the help of cellular microtubules, the virus is transported to the nuclear pore complex, whereby the adenovirus particle disassembles.
35.
The nuclear membrane also has many small holes called nuclear pores that allow material to move in and out of the nucleus.
36.
Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex.
37.
Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells.
38.
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes ( NPCs ) embedded in the nuclear envelope.
39.
Once the cargo is bound, the Ran-exportin-cargo complex moves out of the nucleus through the nuclear pore.
40.
Because the nuclear membrane is impermeable to large molecules, nuclear pores are required to regulate nuclear transport of molecules across the envelope.
