| 31. | Thus, transcription factors can rapidly access their binding sites within nucleosome 1 after being stimulated by a macrophage.
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| 32. | NAD is also consumed by sirtuins, which are NAD-dependent transcription through deacetylating histones and altering nucleosome structure.
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| 33. | This octameric complex, in association with the 147 base pairs of DNA coiled around it, forms the nucleosome.
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| 34. | The H3 2-H4 2 tetramer is wrapped with DNA around it as a first step of nucleosome formation.
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| 35. | The histone-fold domains interaction with the minor groove accounts for the majority of the interactions in the nucleosome.
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| 36. | Within the nucleosome, Kornberg found that roughly 200 bp of DNA are wrapped around an octamer of histone proteins.
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| 37. | For higher resolution maps, this limitation should be overcome to achieve smaller fragments, preferably to single nucleosome resolution.
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| 38. | An activator can also recruit nucleosome modifiers that alter chromatin in the vicinity of the promoter and thereby help initiation.
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| 39. | Unlike histone core proteins, histone tails are not part of the nucleosome core and are exposed to protein interaction.
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| 40. | Anti-dsDNA antibodies might also be created secondary to the production of antibodies to other proteins within the nucleosome.
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