Nalorphine was the second opioid antagonist to be introduced, preceded by nalodeine ( N-allylnorcodeine ) in 1915 and followed by naloxone in 1960 and naltrexone in 1963.
32.
The 14-phenylpropoxy substitution appears to confer potent ?-opioid agonist activity, even when combined with substitutions such as N-cyclopropyl or N-allyl, which normally result in ?-opioid antagonist compounds.
33.
Some studies suggest acupuncture causes a series of events within the central nervous system, and that it is possible to inhibit acupuncture's analgesic effects with the opioid antagonist naloxone.
34.
Although nalbuphine possesses opioid antagonist activity, there is evidence that in nondependent patients it will not antagonize an opioid analgesic administered just before, concurrently, or just after an injection.
35.
Naloxone and naltrexone are commonly used opioid antagonist drugs which are competitive antagonists that bind to the opioid receptors with higher affinity than agonists but do not activate the receptors.
36.
Opioid antagonists such as naltrexone and nalmefene are promising potential treatments for CBD . Naltrexone and nalmefene have also shown effectiveness in the treatment of gambling addiction, an associated disorder.
37.
When rats are given naloxone ( an opioid antagonist ), tickling no longer evokes the 50-kHz vocalisation which indicates that the rewarding properties of tickling are modulated by endogenous opioids.
38.
These effects were not blocked by opioid antagonists such as naloxone, and it was eventually discovered that pravadoline represented the first compound from a novel class of cannabinoid agonists, the aminoalkylindoles.
39.
Surprisingly the main alkaloid from the seeds, akuammine, was found to be an opioid antagonist when tested " in vitro " and canceled out the effects of the active agonist components.
40.
Some opioid antagonists are not pure antagonists but in fact do produce some weak opioid partial agonist effects, and can produce analgesic effects when administered in high doses to opioid-naive individuals.
