When the osteoblast is transformed into an osteocyte, the transformation causes the osteocyte to lose a majority of its organelles.
32.
Even though the function of the osteocyte is still under investigation, there are some ideas on what they might do.
33.
There are promising osteoporosis clinical trials targeting sclerostin, an osteocyte-specific protein which inhibits Wnt signaling by binding to Lrp5.
34.
Osteoblasts are involved in the creation and mineralisation of bone; osteocytes and osteoclasts are involved in the reabsorption of bone tissue.
35.
As the osteoblast transitions to an osteocyte, alkaline phosphatase is reduced, and casein kinase II is elevated, as is osteocalcin.
36.
There are numerous osteocyte lacunae that have a spherical shape within the growth zones, but more lenticular and ordered near growth marks.
37.
It is protective for cartilage cells, and is associated with activation of osteocytes, and thus may be an anabolic factor for bone.
38.
Oxygen tension may regulate the differentiation of osteoblasts into osteocytes, and osteocyte hypoxia may play a role in disuse-mediated bone resorption.
39.
Oxygen tension may regulate the differentiation of osteoblasts into osteocytes, and osteocyte hypoxia may play a role in disuse-mediated bone resorption.
40.
Skeletal unloading has been shown to induce osteocyte M-CSF increases, bone resorption is then enhanced, leading to net bone loss.
