Another interpretation of the analytical data led to the proposal that endogenous ouabain may have been the 11 epimer, i . e ., an isomer of plant ouabain.
32.
The mechanism of selective dye uptake is incompletely understood; vital staining of nerve fibers in skin is prevented by ouabain, a drug that inhibits the Na / K-ATPase of cell membranes.
33.
This gene encodes a catalytic subunit of the ouabain-sensitive H + / K +-ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H + and K + ions across the plasma membrane.
34.
If the ion pumps are turned off by removing their energy source, or by adding an inhibitor such as ouabain, the axon can still fire hundreds of thousands of action potentials before their amplitudes begin to decay significantly.
35.
For instance,-- ATPase found in the membrane of heart cells is an important target of cardiac glycosides ( for example digoxin and ouabain ), inotropic drugs used to improve heart performance by increasing its force of contraction.
36.
Some of the chemicals in the plants are used to produce the drug Ouabain, which was taken as a cardiac stimulant to treat heart failure and sometimes g-strophanthin is advocated as an alternative treatment to more contemporary practices.
37.
In France and Germany, intravenous ouabain has a long history in the treatment of heart failure, and some continue to advocate its use intravenously and " per os " ( orally ) in angina pectoris and myocardial infarction.
38.
Post had recently discovered that three sodium ions were pumped out of the cell for every two potassium ions pumped in, and in his research he had made use of a substance called ouabain which had recently been shown to inhibit the pump.
39.
However, in experiments with patients where the Na + / K +-ATPase had been blocked in the underarm by infusion of the Na + / K +-ATPase-blocker Ouabain, no effect on warm-up was observed.
40.
Based on this scenario, NaKtide, a peptide Src inhibitor derived from-pump, was developed as a functional ouabain-- pump-mediated signal transduction .-pump also interacts with ankyrin, IP3R, PI3K, PLC-gamma and cofilin.
