Most often, H-phosphonate building blocks are protected at the 5'- hydroxy group and at the amino group of nucleic bases A, C, and G in the same manner as phosphoramidite building blocks ( see below ).
32.
For example, the triazole-containing carbocycles by Von Itzstein and Pinto group and the phosphonate analogue of oseltamivir has been reported to show stronger activity resulted from a pertinent binding mode of phosphonate with three Arginine residues in the active site.
33.
For example, the triazole-containing carbocycles by Von Itzstein and Pinto group and the phosphonate analogue of oseltamivir has been reported to show stronger activity resulted from a pertinent binding mode of phosphonate with three Arginine residues in the active site.
34.
Deforolimus ( Ridaforolimus ) has C43 secondary alcohol moiety of the cyclohexyl group of Rapamycin that was substituted with phosphonate and phosphinate groups, preventing the high-affinity binding to mTOR and FKBP . Computational modelling studies helped the synthesise of the compound.
35.
The two ( phosphonate ) groups covalently linked to carbon determine both the name " bis " phospho " nate " and the function of the drugs . " Bis " refers to the fact that there are two such groups in the molecule.
36.
By installing phospho-serine, phospho-threonine or analogous phosphonate mimics into native proteins, researchers are able to perform in vivo studies to investigate the effects of phosphorylation by extending the amount of time a phosphorylation event occurs while minimizing the often-unfavorable effects of mutations.
37.
"' Leopold Horner "'( August 24, 1911 & ndash; October 5, 2005 ) was a German chemist who published a modified Wittig reaction using phosphonate-stabilized carbanions now called the Horner Wadsworth Emmons reaction ( HWE reaction ) or Horner-Wittig reaction.
38.
Alves FC, Donato P, Sherry AD, Zaheer A, Zhang S, Lubag AJ, Merritt ME, Lenkinski RE, Frangioni JV, Neves M, Prata MI, Santos AC, de Lima JJ, Geraldes CF . Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding.
39.
The standard conditions for the Weinreb Nahm ketone synthesis are known to tolerate a wide variety of functional groups elsewhere in the molecule, including alpha-halogen substitution, N-protected amino acids, ?-? unsaturation, silyl ethers, various lactams and lactones, sulfonates, sulfinates, and phosphonate esters.
40.
In addition, the application of systemic ( potassium phosphonate ) with one and double injection ( 20 ml and 40 ml of fungicide for each injection frequency ), and semi-systemic ( metalaxyl ) fungicide showed better control compared to contact fungicides ( copper based fungicide ) in both locations that were used in the experiment.
