And lest we forget that the first recorded use of physostigmine was as a lethal poison, the odd historical accident serves as a reminder.
32.
Drugs that competitively inhibit acetylcholinesterase ( e . g ., neostigmine, physostigmine, or primarily pyridostigmine ) are effective in treating this disorder.
33.
In 1876 he published " Ueber eine neue therapeutische Verwendung des Physostigmin ", suggesting the use of physostigmine for the treatment of glaucoma.
34.
The usual victims of this type of poisoning were children who had swallowed the berries of deadly nightshade, and many were saved by swift treatment with physostigmine.
35.
Another proposed use of physostigmine is to reverse the effects of barbiturates ( any of a group of barbituric acids derived for use as sedatives or hypnotics ).
36.
A suspected overdose with severe life-threatening symptoms should immediately be brought to medical attention, where reversal can be attempted with physostigmine administered intravenously or subcutaneously.
37.
Laqueur is remembered for his research of physostigmine, a chemical substance found in the Calabar bean ( " Physostigma venenosa " ) of West Africa.
38.
In 1934, while working at St Alfege's, Mary Broadfoot Walker first demonstrated the effectiveness of physostigmine in the treatment of the condition myasthenia gravis.
39.
Physostigmine is an ingredient of the Calabar bean that West African tribes used in trials for witchcraft and thus was known as an " ordeal poison ."
40.
The autonomic nervous system also controls another reflex, ejaculation, and in the past few years physostigmine has found a novel application helping paralyzed men who want children.
