The most well-known health issue involving porphobilinogen deaminase is acute intermittent porphyria, an autosomal dominant genetic disorder where insufficient hydroxymethylbilane is produced, leading to a build-up of porphobilinogen in the cytoplasm.
32.
The most well-known health issue involving porphobilinogen deaminase is acute intermittent porphyria, an autosomal dominant genetic disorder where insufficient hydroxymethylbilane is produced, leading to a build-up of porphobilinogen in the cytoplasm.
33.
Four molecules of porphobilinogen combine to form a linear tetrapyrrole, which cyclizes to uroporphyrinogen III . Oxidation and side-chain modifications lead to the synthesis of protoporphyrin IX, which acquires an iron atom to form heme.
34.
"' Porphobilinogen synthase "'( or "'ALA dehydratase "', or "'aminolevulinate dehydratase "') synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid.
35.
"' Porphobilinogen synthase "'( or "'ALA dehydratase "', or "'aminolevulinate dehydratase "') synthesizes porphobilinogen through the asymmetric condensation of two molecules of aminolevulinic acid.
36.
The one protein that is established to function as a morpheein is porphobilinogen synthase, though there are suggestions throughout the literature that other proteins may function as morpheeins ( for more information see " Table of Putative Morpheeins " below ).
37.
Lead ions can replace the native metal ions in several key enzymes, such as zinc cations in the ALAD enzyme, which is also known as porphobilinogen synthase, and is important in the synthesis of heme, a key component of the oxygen-carrying molecule hemoglobin.
