P62 glycosylation is increased in diabetes and may influence its association with other diseases . p62 is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease.
32.
Other causes of KF rings are cholestasis ( obstruction of the bile ducts ), primary biliary cirrhosis and " cryptogenic " cirrhosis ( cirrhosis in which no cause can be identified ).
33.
The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30 % of patients suffering from primary biliary cirrhosis have sp100 Abs.
34.
Established cirrhosis has a 10-year mortality of 34 66 %, largely dependent on the cause of the cirrhosis; alcoholic cirrhosis has a worse prognosis than primary biliary cirrhosis and cirrhosis due to hepatitis.
35.
The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30 % of patients suffering from primary biliary cirrhosis have sp100 Abs.
36.
The autoantibodies for this protein are present in the vast majority of patients with primary biliary cirrhosis, a chronic, progressive cholestatic liver disease that usually affects middle-aged women and eventually leads to liver failure.
37.
This is likewise for several genes involved in medical-relevant phenotypes, such as those affecting systemic lupus erythematosus, primary biliary cirrhosis, Crohn's disease, optic disk size, smoking behavior, interleukin 18 levels, and diabetes mellitus type 2.
38.
Mutations in super-enhancers have been noted in various diseases, including cancers, type 1 diabetes, Alzheimer s disease, lupus, rheumatoid arthritis, multiple sclerosis, systemic scleroderma, primary biliary cirrhosis, Crohn s disease, Graves disease, vitiligo, and atrial fibrillation.
39.
The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary biliary cirrhosis ( PBC; also known as primary biliary cholangitis ).
40.
Coeliac disease is associated with a number of other medical conditions, many of which are autoimmune disorders : diabetes mellitus type 1, hypothyroidism, primary biliary cirrhosis, microscopic colitis, gluten ataxia, psoriasis, vitiligo, autoimmune hepatitis, dermatitis herpetiformis, primary sclerosing cholangitis, and more.
