WNT3 signalling has been shown to be essential in order for the epiblast to acquire responsiveness to the BMP4 signal from the ExE . WNT3 mutants fail to establish a primordial germ cell population, but this can be restored with exogenous WNT activity.
32.
The research has shown that HOX B6 is not expressed in hematopoietic stem cells located in the red bone marrow, which are the precursor cells to all types of blood cells, or primordial germ cells ( PGCs ), the precursor to cells passed on in each generation.
