The history of calpain originates in 1964, when calcium-dependent proteolytic activities caused by a calcium-activated neutral protease ( CANP ) were detected in brain, lens of the eye and other millimolar concentrations of Ca 2 + within the cell, respectively.
32.
Human-identical TPA ( produced industrially by genetically recombinant microorganisms ) has an established medical use in the treatment of ischemic stroke : by its proteolytic activity it enables the action of another enzyme ( plasmin ), which breaks down the protein ( fibrin ) of blood clots.
33.
One purpose of GHBP can be inferred : to maintain the level of GH in the blood, as roughly half of its concentration is complexed with GHBP . Yet this could be confounded by the fact that GH binding to GHBP prevents the ligand from binding to GHR and ultimately proteolytic activity.
34.
Rhinovirus uses protease 3C and 3D to induce cytopathetic effects in the host cell . 3C and 3D act similarly in rhinovirus as they do in poliovirus because they are both involved in early viral infection of the host cell via host cell transcription inhibition by 3C proteolytic activity . 3C and 3CD of Rhinoviruses specifically target OCT-1 transcription factor for proteolytic cleavage.
35.
It grows effectively at high temperatures ( 30-40 �C ) which are typical of the Indonesian islands, it exhibits strong lipolytic and proteolytic activity that create desirable properties in tempeh and it produces metabolites that allows it to inhibit and thus outcompete other molds and gram-positive bacteria, including the potentially harmful " Aspergillus flavus " and " Staphylococcus aureus ".
36.
For the other oligopeptidases, especially those involved in human diseases, the existing studies are promising but not yet as developed as for the ACE . Some examples are : a ) the POP of nervous tissues has been suggested to be involved in neuropsychiatric disorders, like in post-traumatic stress, depression, mania, nervous bulimia, anorexia, and schizophrenia, as reviewed in . c ) the TOP has been involved in tuberculosis Coincidentally, an activity related to the development of nervous tissue has been suggested for POP, nevertheless not involving its proteolytic activity.
