I have little knowledge of the subject, but a quick read on the fever article states " A trigger of the fever, called a pyrogen, causes a release of prostaglandin E2 ( PGE2 ) ".
32.
There would seem to be three factors, the immune response, with the effects of factors such as interferon and pyrogens, toxins produced by the infecting agent, and talk ) 20 : 16, 13 August 2012 ( UTC)
33.
A fever occurs when the viral infection, certain white blood cells within the blood will release pyrogens which have a direct effect on the anterior hypothalamus, causing body temperature to rise, much like raising the temperature setting on a thermostat.
34.
However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.
35.
It is also hypothesized that the OVLT may be the mechanism through which pyrogens function to initiate a febrile response in the CNS . Finally, OVLT neurons have been observed to respond to temperature changes indicating that the organum vasculosum of the lamina terminalis is subject to different climates.
36.
Typical examples of endotoxin binding ligands include histamine, nitrogen-containing heterocyclic compounds, and polymyxin B . However, polymyxin B is known to induce production of interleukin-1, an exogenous pyrogen, and thus must be shown to be absent in the final product if used.
37.
During the " acute phase response " to infection, Kluger notes, the immune system releases pyrogens, or fever-inducing chemicals, and the liver sequesters iron, presumably because, over the eons, animals have found that fevers kill bacteria and that depriving bacteria of the iron they need slows infection.
38.
It's thought that the rise in temperature helps kill off the disease-causing agents, which are often sensitive to small temperature shifts, says Dr . Dale Hyde, a research physiologist in the Thermal Stress Division of the Naval Medical Research Institute in Bethesda, Md . Aspirin lowers temperature by disrupting the action of these pyrogens.
39.
Bartfai s group showed IL-1, then called the endogenous pyrogen, occurs and can be released from the adrenal medulla and brain and demonstrated that the endogenous pyrogen can control body temperature by acting at IL-1 receptors and hyperpolarizing hypothalamic gabaergic interneurons that control thermogenesis in brown adipose tissue ( BAT ), and thus core body temperature and the fever response .,
40.
Bartfai s group showed IL-1, then called the endogenous pyrogen, occurs and can be released from the adrenal medulla and brain and demonstrated that the endogenous pyrogen can control body temperature by acting at IL-1 receptors and hyperpolarizing hypothalamic gabaergic interneurons that control thermogenesis in brown adipose tissue ( BAT ), and thus core body temperature and the fever response .,
