The clustering do "'rescue of stalled replication forks "'and favors normal progress of replication forks.
32.
Replicative polymerases form an asymmetric dimer at the replication fork by binding to sub-units of the clamp loading factor.
33.
At a replication fork arrested at an ICL, FAN1 nuclease action can catalyze incisions in the double-stranded region.
34.
When the replication fork reaches a site of DNA damage it stalls, which can lead to lethal double strand breaks.
35.
Unwinding of DNA at the origin and synthesis of new strands results in replication forks growing bi-directionally from the origin.
36.
In order for DNA replication to occur, a replication fork is created by enzymes called helicases which unwind the DNA helix.
37.
As with prokaryotes, two replisomes are required, one at each replication fork located at the terminus of the replication bubble.
38.
As replication forks spread bidirectionally from origins of replication at ( approximately ) equal speeds, then origin position can be inferred.
39.
The leading strand is the template strand that is being replicated in the same direction as the movement of the replication fork.
40.
FAN1 recruitment and its consequent activity restrain DNA replication fork progression and prevent chromosome abnormalities from occurring when DNA replication forks stall.
