In this research null mutations in the rhodopsin kinase and arrestin genes, each of which plays a role in terminating rhodopsin activity, caused light-dependent retinal degeneration.
32.
Photographing the back of the dilated eye allows the confirmation of bone spicule accumulation in the fundus, which presents during the later stages of RP retinal degeneration.
33.
Alternatively, this mutation may act through the enzyme s anti-apoptotic function, as disrupting the regulation of the hexokinase-mitochondria association by insulin receptors could trigger photoreceptor apoptosis and retinal degeneration.
34.
Using mutants that are defective in late endosome to lysosome trafficking, it was shown that rhodopsin accumulates in endosomal compartments in these mutants and leads to light-dependent retinal degeneration.
35.
For example, Ikeda et al . established that moth1 is a modifier gene of the tub gene, mutations in which cause obesity, retinal degeneration and hearing loss in tubby mice.
36.
The Clinical Investigation Centre covers all eye diseases but is specialised in exploration of retinal pathologies ( macular degeneration, hereditary retinal degenerations, diabetic retinopathies, retinal vascular pathologies ) and technological innovations.
37.
The possibility of altering the course of retinal degeneration through subretinal injection of recombinant replication defective adenovirus that contained the murine cDNA for wildtype PDE6? was tested in " rd1 " mice.
38.
Although there appears to be a relatively narrow treatment window ( after birth but before the retinal degeneration becomes too severe ), mice showed expression and cone function four months after treatment.
39.
Zeng HY, Zhu X, Zhang C, Yang LP, Wu LM, Tso MOM . Identification of Sequential Events and Factors Associated with Microglial Activation, Migration and Cytotoxity in Retinal Degeneration in rd Mice.
40.
The risk of retinal tears and detachment associated with vitreous detachment is higher in patients with myopic retinal degeneration, lattice degeneration, and a familial or personal history of previous retinal tears / detachment.
