If left untreated, patients ultimately develop late sequel, which may include optic atrophy, retinal arterial narrowing, diffuse retinal pigment epithelial changes, and an abnormal electroretinogram.
32.
DasSarma proposed that retinal pigments originally discovered in halophilic Archaea may have predated chlorophyll pigments in the early earth, named the " Purple Earth " hypothesis.
33.
Melanosomes are synthesised in the skin in melanocyte cells, as well as the eye in choroidal melanocytes and retinal pigment epithelial ( RPE ) cells ).
34.
Discs mature along with their distal migration; aged discs shed at the distal tip and are engulfed by the neighboring retinal pigment epithelial cells for degradation.
35.
Dicer's role in this disease became apparent after it was discovered that affected patients showed decreased levels of Dicer in their retinal pigment epithelium ( RPE ).
36.
The inner layer of the optic cup is made of neuroepithelium ( neural retina ), while the outer layer is composed of retinal pigment epithelium ( RPE ).
37.
Following isomerization and release from the opsin protein, all-trans retinal is reduced to all-trans retinol and travels back to the retinal pigment epithelium to be " recharged ".
38.
Mutations in this gene have been associated with disruption of the retinal pigment epithelium ( RPE ) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa ( RP ).
39.
A fundus eye examination that aids in the detection of common vision impairment abnormalities, such as granularity of the retinal pigment epithelium in the central macula will be performed.
40.
Gene MIPEP locates in the same locus and appears to expressed in the retina and retinal pigment epithelium ( RPE ) and are more likely associated with high myopia.
