Paul Ehrlich also proceeded with conspicuous caution in 1909 when introducing the first synthetically produced chemotherapeutic agent against an infectious disease, Salvarsan as a cure for syphilis.
32.
Although arsenic and its compounds are toxic for humans, one of the first synthetic antibiotics was Salvarsan ( the use of which has long been discontinued ).
33.
He introduced an improved Salvarsan preparation for treatment of syphilis, and in 1896 developed a heat-inactivated cholera vaccine that was used extensively during the 20th century.
34.
The medication triggered the so-called " Salvarsan war . " On one side there was hostility on the part of those who feared a resulting moral breakdown of sexual inhibitions.
35.
Some of the side effects attributed to Salvarsan, including rashes, liver damage, and risks of life and limb, were thought to be caused by improper handling and administration.
36.
After extensive clinical testing ( all the research participants had the negative example of tuberculin in mind ) the Hoechst company began to market the compound toward the end of 1910 under the name Salvarsan.
37.
By 1910 Paul Ehrlich and his laboratory group began developing arsenic-based arsphenamine, ( Salvarsan ), as the first effective medicinal treatment of syphilis, and thereby initiated the medical practice of chemotherapy.
38.
Arsphenamine was originally called " 606 " because it was the sixth in the sixth group of compounds synthesized for testing; it was marketed by Hoechst AG under the trade name "'Salvarsan "'in 1910.
39.
To make matters worse, Karen contracts syphilis from her philandering husband ( at the time, cures were uncertain ) and is forced to return to Denmark for a long and difficult period of treatment using the then-new medicine Salvarsan.
40.
He said, �I might have become a German?for there was an effort to create a post for him in Frankfurt, but Ehrlich had just commenced his work on Salvarsan and it was decided that the money over the next two years go to that work.
