In the human testing phase, there is often a group of subjects, one group is given a placebo, and the other is administered a carefully measured therapeutic dose of the drug in question.
32.
Withdrawal effects could occur after treatment, lasting only 2 weeks at therapeutic dose levels; however, withdrawal effects tend to occur with habitual use beyond 2 weeks and are more likely the higher the dose.
33.
This means that even at a therapeutic dose ( 5 �g / kg ), some epibatidine might bind to the muscarinic acetylcholine receptors and cause adverse effects, such as hypertension, bradycardia and muscular paresis.
34.
Many drivers have blood levels far exceeding the therapeutic dose range and often in combination with other alcohol, illegal, or prescription drugs of abuse, suggesting a high degree of abuse potential for benzodiazepines, zolpidem, and zopiclone.
35.
In canines, the effective therapeutic dose was between 76 ng / ml and 99 ng / ml, however the drug reached plasma concentrations of 550 ng / ml without harmful side effects, presenting a desirable therapeutic index.
36.
Erickson, who said baclofen overdose victims routinely stay on respirators for 24 hours, explained that the body can usually rid itself of a therapeutic dose _ 10 to 20 milligrams four times a day _ within 72 hours.
37.
Two iontophoretic patches have recently been approved for vaso-active therapeutic use by the FDA-Zecuity ( 2013 )-containing the migraine drug sumatriptan-and Ionsys ( 2015 ), indicated for moderate-to-severe acute post-operative pain, delivering a therapeutic dose of the powerful opioid, fentanyl, on-demand.
38.
Vitamin A, or retinol, is the sole vitamin which is embryotoxic even in a therapeutic dose, for example in multivitamins, because its metabolite, the retinoic acid, plays an important role as a signal molecule in the development of several tisues and organs.
39.
Merck had already synthesized and patented carbidopa, another dopa decarboxylase inhibitor in 1962, and in 1971 Lotti showed that the use of the L-form of carbidopa, further reduced the therapeutic dose of L-DOPA . The combination of L-carbidopa and L-DOPA was marketed under the brand name of Sinemet.
40.
In a double-center, dose escalation Phase I / IIa clinical trial of BC-819 as a treatment for superficial bladder cancer, no severe adverse events related to the plasmid were detected, and tumor responses were observed in more than 70 % of patients, including those with a still not-optimized therapeutic dose and regimen.
