In mice with hyperuricemia, " Phellodendron amurense " ( whether raw or processed with salt ) reduced blood uric acid levels by inhibiting xanthine oxidase activity.
32.
In addition to inhibition of pro-inflammatory mediators, troxipide directly acts on the enzymes such as xanthine oxidase and myeloperoxidase that generate free oxygen radicals in gastric mucosa.
33.
Since xanthine oxidase is involved in the metabolism of 6-mercaptopurine, caution should be taken before administering allopurinol and 6-mercaptopurine, or its prodrug azathioprine, in conjunction.
34.
Reactive nitrogen species, such as peroxynitrite that xanthine oxidase can form, have been found to react with DNA, proteins, and cells, causing cellular damage or even toxicity.
35.
Xanthine oxidase ( XO ) is an iron molybdenum enzyme, so people with iron deficiency ( the most common cause of anemia in young women ) or molybdenum deficiency can experience hypouricemia.
36.
Most of the protein in the liver exists in a form with xanthine dehydrogenase activity, but it can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification.
37.
Superoxide is also deleterious when produced as a byproduct of mitochondrial respiration ( most notably by Complex I and Complex III ), as well as several other enzymes, for example xanthine oxidase.
38.
A study found that patients with chronic obstructive pulmonary disease ( COPD ) had a decrease in oxidative stress, including glutathione oxidation and lipid peroxidation, when xanthine oxidase was inhibited using allopurinol.
39.
The compound quercinol ( a chromene derivative ), isolated from the oak mazegill, has anti-inflammatory activity, and inhibits the enzymes cyclooxygenase 2, xanthine oxidase, and horseradish peroxidase.
40.
It is one of the cytochromes " b " 5 and belongs to the enzyme super-family of molybdenum oxotransferases that also includes DMSO reductase, xanthine oxidase, and nitrite reductase.
