The Clemmensen reduction is particularly effective at reducing aryl-alkyl ketones, such as those formed in a Friedel-Crafts acylation.
42.
The position between the two carbonyl groups in Meldrum's acid is acidic, allowing simple alkylation and acylation at this position.
43.
Condensation of that with ortho-toluidine leads to the acylation product ( 3 ) formed with a simultaneous loss of carbon dioxide.
44.
This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.
45.
The reaction mechanism of carboxylic acid activation by HATU and subsequent " N "-acylation is summarised in the figure below.
46.
Direct acylations of alcohols with carboxylic acids is preferred over acylations with anhydrides ( poor atom economy ) or acid chlorides ( moisture sensitive ).
47.
Direct acylations of alcohols with carboxylic acids is preferred over acylations with anhydrides ( poor atom economy ) or acid chlorides ( moisture sensitive ).
48.
Related to the latter is the classical preparation of the dye fluorescein from phthalic anhydride and resorcinol, which involves a Friedel-Crafts acylation.
49.
The alkylation reaction is more widely used than the acylation reaction, although its practice is more technically demanding because the reaction is more sluggish.
50.
Acylation is much more straightforward as the resulting ?-cyanocarbonyl compounds are much more acidic ( and less nucleophilic ) than corresponding starting materials.
