| 41. | The toxicity, carcinogenity, and paradoxically, cancer cell-killing abilities of different DNA alkylating agents are an example.
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| 42. | "' Fotemustine "'is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma.
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| 43. | Preferred N attack, as postulated for hard electrophiles by the HSAB principle, could not be observed with any alkylating agent.
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| 44. | XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents.
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| 45. | The "'AidB "'protein has been supposed to take part in the degradation of endogenous alkylating agents.
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| 46. | Additionally, the group cannot produce cross-reacting Michael acceptors that could act as alkylating agents towards nucleophilic species within cells.
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| 47. | Because it is a highly reactive alkylating agent and it is inherently unstable, it had been described as a metabolic poison.
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| 48. | Although cisplatin is frequently designated as an alkylating agent, it has no alkyl group and it therefore cannot carry out alkylating reactions.
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| 49. | "' Ranimustine "'( alkylating agent approved in Japan for the treatment of chronic myelogenous leukemia and polycythemia vera.
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| 50. | Thus, the leaving group X in the alkylating agent R-X can be chloride, bromide, iodide, or tosylate.
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