| 41. | The cell cycle surveillance mechanism that prevents sister-chromatid separation and transition into anaphase is called the spindle checkpoint.
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| 42. | Geminin was originally identified as an inhibitor of DNA replication and substrate of the anaphase promoting complex ( APC ).
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| 43. | Moreover, survivin has been shown to localize to components of the mitotic spindle during metaphase and anaphase of mitosis.
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| 44. | This regulatory role may be directly associated with the role of topoisomerase II in disjoining sister chromatids prior to anaphase.
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| 45. | As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase
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| 46. | The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase.
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| 47. | Concurrently, anaphase-promoting complex ( APC ) activity decreases significantly, allowing S and M cyclins to become activated.
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| 48. | Genetic mosaicism can result from many different mechanisms including chromosome non-disjunction, anaphase lag and endoreplication . [ 1]
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| 49. | Microtubule attachment at all of the kinetochore binding sites is not necessary for deactivation of the SAC and progression to anaphase.
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| 50. | Monopolin is required for the segregation of homologous centromeres to opposite poles of a dividing cell during anaphase I of meiosis.
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