Researchers found that antithrombin, a protein that controls the formation of blood clots, changes in molecular shape to become a cancer fighter.
42.
Antithrombin I ( AT I ) refers to the absorption of thrombin onto fibrin after thrombin has activated fibrinogen . plasma that inactivates thrombin.
43.
Studies in animals and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time.
44.
Heparin ( unfractionated heparin ) and its derivatives antithrombin ( AT ) to inactivate several coagulation factors IIa, Xa, XIa and XIIa.
45.
The transgenic goats, carrying the gene for antithrombin III, were made by microinjecting embryos, the standard transgenic procedure that cloning may replace.
46.
The physiological target proteases of antithrombin are those of the " tissue factor pathway " ( formerly known as the extrinsic pathway ).
47.
Unlike direct factor Xa inhibitors, it mediates its effects indirectly through antithrombin III, but unlike heparin, it is selective for factor Xa.
48.
The rate of antithrombin's inhibition of protease activity is greatly enhanced by its additional binding to heparin as is its inactivation by neutrophil elastase.
49.
Hypercoagulability can be promoted by increased platelet count, enhanced platelet aggregation, increased protein S count, and a decrease in coagulation inhibiters like antithrombin.
50.
In one mechanism heparin stimulation of Factor IXa and Xa inhibition depends on a conformational change within antithrombin involving the reactive site loop and is thus allosteric.
