His laboratory further supported these concepts by demonstrating a deficit of docosahexaenoic and arachidonic acid in Usher s syndrome.
42.
Polyunsaturated fatty acids, particularly arachidonic acid and linoleic acid, are primary targets for free radical and singlet oxygen oxidations.
43.
One possible downstream target of several mood stabilizers such as lithium, valproate, and carbamazepine is the arachidonic acid cascade.
44.
CYP4F8 and CYP4F12 likewise possess both monooxygenase activity for arachidonic acid and epoxygenase activity for docosahexaenoic and eicosapentenoic acids.
45.
EPHX1 also metabolizes endocannabinoid 2-arachidonoylglycerol to arachidonic acid and may play an important role in the endocannabinoid signaling pathway.
46.
Most notably, the formation of prostaglandin H2 from arachidonic acid which is very similar in structure to mead acid.
47.
It is hypothesized that DHA and arachidonic acid could improve memory function by interacting with FFA1 in the hippocampus neurons.
48.
Prostanoid receptors bind and respond principally to metabolites of the straight chain polyunsaturated fatty acid ( PUFA ), arachidonic acid.
49.
When physiological levels of arachidonic acid are low, other unsaturated fatty acids including mead and linoleic acid are oxidized by COX.
50.
NE uptake leads to an increase in intracellular astrocyte phospholipase A ( PLA ) is activated which in turn mobilizes arachidonic acid.
