Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function.
42.
Recent research indicates that the skin abnormalities seen in XLI may be due to accumulation of cholesterol sulfate in the outer epidermis, leading to abnormal barrier function and corneocyte retention.
43.
Natural selection would have favored mutations that protect this essential barrier; one such protective adaptation is the pigmentation of epidermis, because it improves barrier function as compared to non-pigmented skin.
44.
Unlike the conventional moisturizers made with humectants or emollients, MLE can restore and improve the barrier function of skin, with its distinctive structural similarity to the native human skin's lamellar structure.
45.
It was long unclear whether tight cell junctions also play any role in the barrier function of the skin and similar external epithelia but recent research suggests that this is indeed the case.
46.
This implies the importance of AGR2 in maintaining epithelial barrier function, which is supported by FOXA1 and FOXA2 molecules ( transcription factors for epithelial goblet cells ) which can activate the AGR2 promoter.
47.
At higher temperatures even relatively mild chemicals have sufficient oxide-disrupting activity, but the metal oxidation rates become fairly high; the barrier function of the vehicle therefore becomes more important than the fluxing activity.
48.
Some moisturizers tend to weaken the skin barrier function, but studies on xerosis have proven that moisturizers containing humectants increase desired moisturizing effects on the affected area without damage to the skin barrier function.
49.
Some moisturizers tend to weaken the skin barrier function, but studies on xerosis have proven that moisturizers containing humectants increase desired moisturizing effects on the affected area without damage to the skin barrier function.
50.
It has also been observed that mesalazine therapy helps to normalise the gut flora which is often abnormal in people who have IBS . The therapeutic benefits of mesalazine may be the result of improvements to the epithelial barrier function.
