IgE primes the IgE-mediated allergic response by binding to Fc receptors found on the surface of mast cells and basophils.
42.
Crosslinking of the Fc?RI via IgE-antigen complexes leads to degranulation of mast cells or basophils and release of inflammatory mediators.
43.
Under laboratory conditions, degranulation of isolated basophils can also be induced with antibodies to the Fc?RI?, which crosslink the receptor.
44.
Several minutes at room temperature gives the marker time to bind to the CD63 proteins on the cell membrane of the basophil.
45.
Recent evidence suggests that basophils are an important source of the cytokine, interleukin-4, perhaps more important than T cells.
46.
Injured basophils and other leukocytes will release another substance called prostaglandins that contributes to an increased blood flow to the site of infection.
47.
The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.
48.
Recent studies in mice suggest that basophils may also regulate the behavior of T cells and mediate the magnitude of the secondary immune response.
49.
As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.
50.
The lipoxygenase pathway is active in leukocytes and other immunocompetent cells, including mast cells, eosinophils, neutrophils, monocytes, and basophils.
