Mechanistically, the reaction proceeds with potassium hydroxide deprotonating a methyl group and the resulting carbanion undergoing nucleophilic substitution with methyl iodide to form a new carbon carbon bond.
42.
My hypothesis is that the inductive effect is also at play, where having a carbanion resonance structure next to a ( protonated ) oxygen atom will stabilise it somewhat.
43.
Next, a series of condensation reactions of three acetate units from malonyl-CoA occurs, each proceeding through an acetyl-CoA carbanion derived from malonyl-CoA decarboxylation.
44.
An alternative mechanism does not involve a free carbene intermediate, but rather involves attack of the carbanion by a second molecule of trimethylphosphite with concomitant cleavage of the sulfur-carbon bond.
45.
I really can't see an acidic proton in nitromethane . . . unless nitromethide carbanion is really that stable ? talk ) 02 : 19, 12 December 2009 ( UTC)
46.
This fragment is then able to react with the masked carbanion formed from the PLP mediated decarboxylation of L-Serine, which cyclizes in a dehydration reaction to yield the second pyrrole ring.
47.
Nucleophilic addition of a carbanion or another nucleophile to the double bond of an alpha, beta unsaturated carbonyl compound can proceed via the Michael reaction, which belongs to the larger class of conjugate additions.
48.
The negative charge placed on this position ( formally a carbanion ) is transferred to the halogen residing on the other ?-position in a nucleophilic displacement temporarily forming a three-membered cyclic sulfone.
49.
A 2.0-methylene carbanion, generated by enzyme catalyzed proton removal and stabilized by electrostatic interactions in the tunnel, on the C-7 carbonyl ( see 3 in Figure 1 ).
50.
:: : An sp hybridized carbon also has a higher electronegativity than sp2 and sp3, making the resulting carbanion relatively stable .-- talk ) 20 : 01, 30 October 2008 ( UTC)
