While the initial attraction between cardiolipin and cytochrome c is electrostatic due to the extreme positive charge on cytochrome c, the final interaction is hydrophobic, where a hydrophobic tail from cardiolipin inserts itself into the hydrophobic portion of cytochrome c.
42.
Lee s study looked into the consequences of cardiolipin redistribution in the mitochondria and found that cardiolipin plays a critical role in proteins that are involved with oxidative respiration ( such as ATP synthase ), which in turn affects ATP production.
43.
Lee s study looked into the consequences of cardiolipin redistribution in the mitochondria and found that cardiolipin plays a critical role in proteins that are involved with oxidative respiration ( such as ATP synthase ), which in turn affects ATP production.
44.
Finding that cardiolipin concentration in the outer mitochondrial membrane increased during apoptosis ( as well as knowing the function that PLS3 plays in mitochondrial apoptotic effects ) clued Lee in to the fact that PLS3 may have effects on this cardiolipin membrane redistribution.
45.
Finding that cardiolipin concentration in the outer mitochondrial membrane increased during apoptosis ( as well as knowing the function that PLS3 plays in mitochondrial apoptotic effects ) clued Lee in to the fact that PLS3 may have effects on this cardiolipin membrane redistribution.
46.
It is not known what triggers changes in complex assembly, but research has revealed that the formation of supercomplexes is heavily dependent upon the lipid composition of the mitochondrial membrane, and in particular requires the presence of cardiolipin, a unique mitochondrial lipid.
47.
In Lee's experiment determining the effect of cardiolipin deprivation on cells, he studied an infected yeast mutant that lacked a cardiolipin creating enzyme, and found that although it was viable, the yeast was " moderately deficient in mitochondrial energy transforming machinery ."
48.
In Lee's experiment determining the effect of cardiolipin deprivation on cells, he studied an infected yeast mutant that lacked a cardiolipin creating enzyme, and found that although it was viable, the yeast was " moderately deficient in mitochondrial energy transforming machinery ."
49.
The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent, whereas those that occur in the antiphospholipid antibody syndrome ( associated to lupus for example ) are beta-2 glycoprotein dependent, and this can be used to tell them apart in an ELISA assay.
50.
Recurrent miscarriage is an indication for thrombophilia screening, particularly antiphospholipid antibodies ( anti-cardiolipin IgG and IgM, as well as lupus anticoagulant ), factor V Leiden and prothrombin mutation, activated protein C resistance and a general assessment of coagulation through an investigation known as thromboelastography.
