| 41. | Chloroquine enters the red blood cell, inhibiting the parasite cell and digestive vacuole by simple diffusion.
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| 42. | Chloroquine and S / P are extremely cheap, as little as 20 cents for an adult treatment.
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| 43. | Chloroquine is nearly useless, Sunkutu said, and S / P resistance is reported at 16 percent.
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| 44. | Chloroquine, a cheap and effective wonder drug, was used indiscriminately for years and is now failing.
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| 45. | Since the 1960s, strains resistant to chloroquine, the primary treatment, have spread around the world.
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| 46. | Nalidixic acid was discovered by George Lesher and coworkers in a distillate during an attempt at chloroquine synthesis.
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| 47. | Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion.
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| 48. | The best-understood examples of such hematin biocrystallization inhibitors are quinoline drugs such as chloroquine and mefloquine.
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| 49. | Chloroquine resistance was first observed in 1962 in the area with the lowest relative uptake of chloroquinized salt.
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| 50. | Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.
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