More recent studies have more definitively identified ART-27 as a corepressor of AR . The fact that the increase in gene transcription exhibited upon ART-27 depletion requires the presence of AR implies that it specifically functions as a corepressor of this receptor.
42.
More recent studies have more definitively identified ART-27 as a corepressor of AR . The fact that the increase in gene transcription exhibited upon ART-27 depletion requires the presence of AR implies that it specifically functions as a corepressor of this receptor.
43.
While this article refers to the historical terms " coactivator " and " corepressor " it should be noted that this distinction is less clear than was at first thought, and it is now known that cell type, cell signaling state and promoter identity can influence the direction of action of any given coregulator.
44.
In addition to the transcriptional repressor ( corepressor ) discussed above, there is a longer isoform that is a major component of specialized synapses known as 3'- untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely.
45.
The encoded protein is an integral subunit of the NCOR1-HDAC3 ( nuclear receptor corepressor 1-histone deacetylase 3 ) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 ( activator protein 1 ) function.
46.
In turn, a variety of coactivators are implicated in transcriptional activation by nuclear receptors, including SWI / SNF chromatin remodeling machines, SRC / p160s and TRAP / DRIP . The model accommodates the ability of membrane G protein coupled signaling pathways and tyrosine receptor signaling to cross-talk with coactivator and corepressor functions at the transcriptional level.
47.
Thus, the binding of Wnt to the receptor results in a non-phosphorylated form of ?-catenin which localizes to the nucleus and, after displacing the Groucho corepressor protein, forms a complex with Tcf / Lef transcription factors and co-activators ( such as CREB binding protein ) and induces the expression of downstream target genes.
