For instance, Cyclooxygenase-2 enzyme ( Cox-2 ) expression is elevated in a range of cancers, and has low liver expression, making it a suitable tumour-specific promoter . " AdCox2Lluc " is a CRAd targeted against oesophageal adenocarcinoma by placing the early genes under the control of a Cox-2 promoter ( adenoviruses have two early genes, E1A and E1B, that are essential for replication ).
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For instance, Cyclooxygenase-2 enzyme ( Cox-2 ) expression is elevated in a range of cancers, and has low liver expression, making it a suitable tumour-specific promoter . " AdCox2Lluc " is a CRAd targeted against oesophageal adenocarcinoma by placing the early genes under the control of a Cox-2 promoter ( adenoviruses have two early genes, E1A and E1B, that are essential for replication ).
