People with Tay & ndash; Sachs disease are unable to remove the GalNAc residue from the G M2 ganglioside, and as a result, they end up storing 100 to 1000 times more G M2 gangliosides in the brain than the normal person.
42.
Racotumomab triggers an immune response against the tumor antigen N-glycolil ( NGc ) GM3 ( NGcGM3 ), a type of ganglioside present on the cell surface of malignant cells from lung and breast, melanoma, as well as neuroectodermal pediatric tumors.
43.
These include Sygen, or GM-1 ganglioside, a drug used in 1992 to treat the football player Dennis Byrd of the New York Jets, who regained the ability to walk after a paralyzing neck injury, and Freedox, the subject of a 15-center national trial.
44.
Genetic defects in " HEXB " can result in the accumulation of GM2 ganglioside in neural tissues and two of three lysosomal storage diseases collectively known as GM2 gangliosidosis, of which Sandhoff disease ( defects in the " ? " subunit ) is the best studied one.
45.
Using an edible algae produced fusion protein of the malaria membrane protein pfs25 and the ganglioside binding protein ctxB, researchers were able to induce production of IgG antibodies, which are the most common antibodies in circulation, was not found in mice that were only immunized solely via the edible algae vaccine.
46.
"' Sandhoff disease "', also known as "'Sandhoff-Jatzkewitz disease "', "'variant 0 of GM2-Gangliosidosis "'or "'Hexosaminidase A and B deficiency "', is a lysosomal genetic, lipid storage disorder caused by the inherited deficiency to create functional beta-hexosaminidases A and B . These catabolic enzymes are needed to degrade the neuronal membrane components, ganglioside GM2, its derivative GA2, the glycolipid globoside in visceral tissues, The rare autosomal recessive neurodegenerative disorder is clinically almost indistinguishable from Tay-Sachs disease, another genetic disorder that disrupts beta-hexosaminidases A and S . There are three subsets of Sandhoff disease based on when first symptoms appear : classic infantile, juvenile and adult late onset.
