| 41. | Dibutyl phthalate ( DBP ) has also disrupted insulin and glucagon signaling in animal models.
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| 42. | Also, glucagon levels do not increase.
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| 43. | Importantly, insulin secretion is suppressed in this fasted state and glucagon secretion is increased.
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| 44. | Glucagon is now thought to act exclusively on the liver to trigger glycogenolysis and gluconeogenesis.
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| 45. | It also decreases glucagon secretion in a glucose-dependent manner and delays gastric emptying.
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| 46. | The hypothalamus also sends signals to the pancreas to release insulin and to suppress glucagon.
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| 47. | This is why glucagon has been known for decades as a counter-regulatory hormone.
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| 48. | Diabetes reflects insulin deficiency and glucagon abundance.
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| 49. | Drug interactions : Glucagon interacts only with oral anticoagulants, increasing the tendency to bleed.
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| 50. | Glucagon turns off glycolysis in the liver, causing glycolytic intermediates to be shuttled to gluconeogenesis.
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