Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.
42.
The O-linked glycan chains predominantly contain galactose, arabinose, rhamnose, mannose, galacturonic acid and / or glucuronic acids and have a relatively high degree of polymerization, with a structure similar to arabinogalactan II.
43.
It is a precursor of glycogen and can be converted into UDP-galactose and UDP-glucuronic acid, which can then be used as substrates by the enzymes that make polysaccharides containing galactose and glucuronic acid.
44.
There is no internationally accepted molecular standard for the composition of heparin, as it is a complex polymer of GAG units and uronic acids ( including D-glucuronic acid, L-iduronic acid, and D-glucosamine ).
45.
It is a precursor of glycogen and can be converted into UDP-galactose and UDP-glucuronic acid, which can then be used as substrates by the enzymes that make polysaccharides containing galactose and glucuronic acid.
46.
Moreover, glucuronolactone is hydrolyzed in the body ( like butyrolactone ) to glucuronic acid, which may be oxidized to glucaric acid, or isomerized to another hexuronic acid, so there is no reasonable toxicity mechanism.
47.
The reaction catalyzed by the UGT enzyme involves the addition of a glucuronic acid moiety to xenobiotics and is the most important pathway for the human body's elimination of the most frequently prescribed drugs.
48.
With his pupil Hans Horst Meyer he discovered glucuronic acid as a conjugation partner in xenobiotic metabolism and later found that glucuronic acid was also a component of cartilage and occurred as a disaccharide of chondroitin sulfate.
49.
With his pupil Hans Horst Meyer he discovered glucuronic acid as a conjugation partner in xenobiotic metabolism and later found that glucuronic acid was also a component of cartilage and occurred as a disaccharide of chondroitin sulfate.
50.
The innate utilization of sugars as solubilizing moieties in Phase II and III metabolism ( glucuronic acids ) has remarkably allowed an evolutionary advantage in that mammalian enzymes are not directly evolved to degrade O glycosylated products on larger moieties.
