The most common application of Grignard reagents is the alkylation of aldehydes and ketones, i . e . the Grignard reaction:
42.
Polar aprotic solvents are generally incompatible with strong bases, such as Grignard reagents or " n "-butyllithium.
43.
Reformatsky enolates are less reactive than lithium enolates or Grignard reagents and hence nucleophilic addition to the ester group does not occur.
44.
The imine is then reacted with an Grignard reagent to the corresponding magnesium salt to an intermediate capable of displacing a halide.
45.
For the coupling of aryl halides with aryl Grignard reagents, nickel chloride in tetrahydrofuran ( THF ) is also a good catalyst.
46.
The catalytic species in these reactions is proposed to be an " inorganic Grignard reagent " consisting of Fe ( MgX ) 2.
47.
Organometallic compounds, such as organolithium reagents, Grignard reagents, or acetylides, undergo nucleophilic addition reactions, yielding a substituted alcohol group.
48.
Alternatively, non-nucleophilic Grignard reagents such as isopropyl magnesium chloride can be used to activate the amine before addition of the ester.
49.
It is known that magnesium center in Grignard reagents typically coordinates two molecules of ether such as diethyl ether or tetrahydrofuran ( THF ).
50.
Ph 2 Se 2 is prepared by the oxidation of benzeneselenoate, the conjugate base of benzeneselenol which is generated via the Grignard reagent:
