Homozygosity / Autozygosity mapping is a powerful technique, but is only valid when searching for a mutation segregating within a small, closed population.
42.
A study of Arab women found that proline homozygosity at " TP53 " codon 72 is associated with a decreased risk for breast cancer.
43.
The correlation with genome-wide homozygosity likely reflects the serial founder effect that was initiated with the ancient successive out-of-Africa migrations.
44.
Single queen colonies of the narrow headed ant " Formica exsecta " provide an illustrative example of the possible deleterious effects of increased homozygosity.
45.
Furthermore, if two suspicious regions appear as a result of homozygosity mapping, autozygosity mapping may be able to distinguish between the two ( ex.
46.
In sFI, there is no mutation in " PRNP "-prion gene in D178N, but all have methionine homozygosity at codon 129.
47.
Worker homozygosity appeared to affect reproductive allocation, with higher homozygosity being associated with less resources being allocated to the sexual brood and more to worker production.
48.
Worker homozygosity appeared to affect reproductive allocation, with higher homozygosity being associated with less resources being allocated to the sexual brood and more to worker production.
49.
Furthermore, homozygosity and the expression of deleterious recessive mutations as consequences of inbreeding have likely resulted in the purging of severely deleterious mutations from the population.
50.
Oocytes that undergo automixis with central fusion often display a reduced rate of heterozygosity, and only a slow transition from heterozygosity to homozygosity over successive generations.
