For comparative purposes, they also tested tyramine and N, N-dimethyltyramine ( hordenine ) in their assay, finding that 83 nM / kg ( corresponding to 12.5 ?g / kg of NMT ) of each compound enhanced gastrin release by ~ 58 % for NMT, ~ 24 % for tyramine, and ~ 60 % for hordenine.
42.
For comparative purposes, they also tested tyramine and N, N-dimethyltyramine ( hordenine ) in their assay, finding that 83 nM / kg ( corresponding to 12.5 ?g / kg of NMT ) of each compound enhanced gastrin release by ~ 58 % for NMT, ~ 24 % for tyramine, and ~ 60 % for hordenine.
43.
In a survey of the ability of a wide range of arylalkylamines and their derivatives to release norepinephrine ( NE ) from mouse heart, Daly and co-workers determined that 10 mg hordenine sulfate did not cause any significant NE release, in contrast to the same doses of the closely related compounds N-methyltyramine hydrochloride ( which released 36 % over control ) and tyramine hydrochloride ( which released 50 % over control ).
44.
From experiments aimed at identifying the toxin responsible for producing the locomotor disorder ( " staggers " ) and rapidly lethal cardiac toxicosis ( " sudden death " ) periodically observed in livestock feeding on the grass " Phalaris aquatica ", Australian researchers determined that the lowest doses of hordenine that would induce symptoms of " staggers " in sheep were 20 mg / kg i . v ., and 800 mg / kg orally.
